Loeb S, Bjurlin MA, Nicholson J, Tammela TL, Penson DF, Carter HB, Carroll P, Etzioni R.
“Overdiagnosis and Overtreatment of Prostate Cancer.”
European Urology 2014; epub Jan 9. PMID: 24439788
Link: http://www.ncbi.nlm.nih.gov/pubmed/24439788
This systematic review of epidemiological, clinical and autopsy studies found a very wide of estimates for prostate cancer overdiagnosis from 1.7-67%. Published estimates of overtreatment vary widely based on patient features and may be declining internationally. Careful patient selection for screening and reducing overtreatment are important to preserve the benefits and reduce the downstream harms of prostate-specific antigen testing.