Loeb S, Makarov DV, Schaeffer EM, Humphreys EB, and Walsh PC.
“Prostate-specific antigen at the initial diagnosis of metastasis to bone in patients after radical prostatectomy.”
Journal of Urology, July 2010; 184: 157.
Link: http://www.ncbi.nlm.nih.gov/pubmed/20483148
In men with newly diagnosed prostate cancer, bone metastases are uncommon at PSA levels <20 ng/ml. However, after radical prostatectomy bone metastases may occur at much lower PSA levels. Among 193 hormone naïve men who developed bone metastases after radical prostatectomy, bone scan conversion occurred at a PSA <10, 10-100 and >100 ng/ml in 26%, 51% and 23% men, respectively.