Ross AE, Loeb S, Landis P, Partin AW, Epstein JI, Kettermann A, Feng Z, Carter HB, and Walsh PC.
“Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance program.”
Journal of Clinical Oncology, June 2010; 28: 2810.
Link: http://www.ncbi.nlm.nih.gov/pubmed/20439642
PSA doubling time and PSA velocity are frequently used to monitor patients during active surveillance. Among men in the Johns Hopkins active surveillance program, PSA kinetics during active surveillance were not reliable predictors of adverse pathology on repeat biopsy. This suggests that PSA kinetics should not be used as a trigger for intervention during active surveillance.